Health


Autoimmunity

Regional Factors Driven by Genetic Diversity Add Complexity to Autoimmune Disease Drug Development

24.07.2008 19:53:55 Applied Data Research Survey Examines Evolving Technology and Strategic Factors

(live-PR.com) - (Nashua, NH) – As a group, autoimmune diseases remain one of the most refractory and difficult-to-treat segments of healthcare therapeutics. The underlying genetics of the immune response and the complexities they foster among individual patients make this one of the most challenging areas in all of life science. Until recently, autoimmune disease patients were given little hope for effective treatment. But the convergence of improved elucidation of autoimmune disease mechanisms and the ability to design and manufacture recombinant proteins capable of attenuating the immune system cascade has led to systemic treatments that have demonstrated the ability to provide some degree of relief from autoimmune symptoms in a significant number of patients.


Perhaps more than any other disease segment, autoimmune conditions and the companies that market treatments for them are benefiting from the potential for expanded indications. A typical strategy for many drug candidates is to initially target a larger, well-defined segment such as Rheumatoid Arthritis and then pursue secondary indications – for example – Lupus or Psoriasis, once the brand has been launched and established. Such a strategy requires resources and risks that can strain all but the largest players, making alliances highly attractive.

Because of the individual genetic variability underlying the incidence and severity of autoimmune symptoms, regional variations in the market for autoimmune therapeutics can be significant. This variability is compounded by differences in treatment protocols and cultural factors, which combine to make alliance partnerships with regional players of increased importance.

The dynamics of therapeutic intellectual property is another factor fostering alliance activity in the autoimmune sector. Because antibody technology forms the basis for much of the current generation of autoimmune disease treatment technology, mid-to-large pharma companies are increasingly in-licensing therapeutic candidates from smaller specialty laboratories, often at the pre-clinical stage.

More information is also available at www.applieddata.org/Autoimmune_Disease.htm

About Applied Data

Applied Data Research is a healthcare therapeutics consulting firm focused on medical market strategies, product commercialization, venture development, and market research. We assist medical market participants in achieving their business objectives through the creation of detailed business development strategies, product commercialization programs, and comprehensive market and technology research and analysis.


Contact:

Greg Stone
Voice: 603-595-6225
Fax: 603-804-0466
www.applieddata.org

Source: Applied Data Research


Press Information:
Applied Data Research

98 Amherst Street
Amherst, NH 03031

Contact Person:
Greg Stone
Communications Director
Phone: 603-595-6225
eMail: eMail

Web: http://www.applieddata.org



 

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